Role of free L-carnitine and acetyl-L-carnitine in post-gonadal maturation of mammalian spermatozoa
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چکیده
منابع مشابه
The Effects of L-carnitine and L-acetyl- carnitine on in vitro sperm maturation
Received: 13 November 2010 Revised: 16 May 2011 Accepted: 15 June 2011 Abstract Background: Sperm cells extracted from testes (TESE) have poor chromatin quality and motility. Various substances are used in the laboratory to increase sperm motility and improve the ART outcomes; however, there are few research which considered improving both sperm motility and chromatin quality. Objective: The ai...
متن کاملAcetyl-L-Carnitine Monograph
Introduction Acetyl-L-carnitine (ALC) is an ester of the trimethylated amino acid, L-carnitine, and is synthesized in the human brain, liver, and kidney by the enzyme ALC-transferase. Acetyl-L-carnitine facilitates the uptake of acetyl CoA into the mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane phospholipid synthesis. ALC, simila...
متن کاملEvaluation of the protective effect of L-carnitine and acetyl-L-carnitine on human spermatozoa during freezing and thawing
Materials and methods: Semen samples were collected from 20 normal healthy volunteers. Specimens were divided into 2 aliquots (A and B) and each diluted in Ham's F-10 media to a uniform concentration of 20X10/mL. Aliquots A, were further divided and into each L-carnitine or acetyl-L-carnitine were added in concentrations of 0, 10, and 30 μM separately. All aliquots were cryopreserved for 3 days...
متن کاملComparison of pharmacokinetics of L-carnitine, acetyl-L-carnitine and propionyl-L-carnitine after single oral administration of L-carnitine in healthy volunteers.
PURPOSE To investigate the pharmacokinetics of L-carnitine (LC) and its analogues, acetyl-L-carnitine (ALC) and propionyl-L-carnitine (PLC) in healthy volunteers after single L-carnitine administration. METHODS Liquid L-carnitine (2.0 g) was administered orally as a single dose in 12 healthy subjects. Plasma and urine concentrations of L-carnitine, ALC and PLC were detected by HPLC. RESULTS...
متن کاملEffects of L-carnitine and L-acetyl-carnitine on testicular sperm motility and chromatin quality
BACKGROUND Sperm cells extracted from testes (TESE) have poor chromatin quality and motility. Various substances are used in the laboratory to increase sperm motility and improve the ART outcomes; however, there are few research which considered improving both sperm motility and chromatin quality. OBJECTIVE The aim of this investigation was to evaluate the improvement of the testicular sperm ...
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ژورنال
عنوان ژورنال: Human Reproduction Update
سال: 1996
ISSN: 1355-4786,1460-2369
DOI: 10.1093/humupd/2.2.87